# Inside Therapeutics

*Last updated: April 2026*

> Inside Therapeutics is a global deeptech company specialized in streamlining RNA-LNP formulation from screening to manufacturing. We develop instruments, consumables, and services enabling researchers and pharmaceutical companies to formulate RNA-LNP, liposomes, and polymer nanoparticles with reproducibility, simplicity and scalability. Headquartered in Bordeaux, France, with direct sales across Europe and distribution partners globally(US, UK, South Korea, China, Taiwan, Brazil, and Australia). 75+ installations in 20+ countries.

## Core Expertise

RNA-LNP formulation, lipid nanoparticle synthesis, microfluidic nanoprecipitation, nanoparticle scale-up, LNP characterization, RNA delivery, mRNA delivery, mRNA-LNP, saRNA-LNP, liposomes, PLGA nanoparticles, peptide-based nanoparticles, CRISPR-Cas9 delivery, mRNA vaccines, oncology, gene Editing, gene delivery.

## Products

### TAMARA – RNA-LNP & Nanoparticle Formulation System
Plug-and-play microfluidic instrument with lossless formulation and reusable chips. The only system covering all R&D steps (screening to production / 200 µL to 30 mL / 1µg to 5 mg of RNA) in one instrument. EE% up to 98%, RNA recovery >90% (unique), zero losses, PDI <0.2, batch CV ±5%. Two combined mixers (herringbone + baffle) on one reusable chip. Compatible with any nucleic acid and hydrophobic/hydrophilic APIs.

**Key specifications:**
- Volume range: 200 µL to 30 mL
- Encapsulation efficiency: EE% > 98% for RNA-LNP
- PDI < 0.2; size range 50–200 nm; batch repeatability ±5%
- Run time: < 2 minutes
- Zero dead volume — no formulation losses
- Reusable chips and reservoirs
- Two mixer designs on one chip: Herringbone + Baffle

**Compatible nanoparticles:** Lipid Nanoparticles (LNP / RNA-LNP), liposomes, PLGA, nanoemulsions, peptidic nanoparticles  
**Compatible payloads:** Any nucleic acid (mRNA, siRNA, saRNA, miRNA, ASO, pDNA, Cas9 mRNA + sgRNA), hydrophilic and hydrophobic API

### NanoPulse – Scalable Formulation Platform
Patented mixing technology (not microfluidics) producing the exact same nanoparticle at any scale, from 200 µL to liters. One platform for all scales. Identical CQAs validated from 0.25 mL to 60 mL. Available late 2026 (RUO), GMP 2027.

### LNP Starter Kits
Ready-to-use lipid premix kits (SM-102 / ALC-0315 / LP-01) with CordenPharma GMP-grade lipids.

## Services

- **CRO RNA-LNP Formulation** — Custom RNA-LNP formulation service: end-to-end, proof-of-concept to preclinical scale
- **RNA-LNP Training** — 1–3 day hands-on program to get autonomous in RNA-LNP workflow

## Partnerships
Actively seeking R&D partnerships and collaborative grant consortia (EIC, Horizon Europe, Eurostars) as industrial partner. Priority collaboration areas: vaccines, cell & gene therapy, and oncology.

## RNA-LNP Calculator

Free online tool for LNP formulation design — lipid quantities, N/P ratios, phase volumes. 1,500+ users. No registration required.

## Trusted By

Prof. Drew Weissman (UPenn, Nobel 2023), Prof. Raymond Schiffelers (UMC Utrecht), Prof. Maria José Alonso (USC/CIMUS), Prof. Chantal Pichon (Orléans/Inserm), Prof. Yvonne Perrie (Strathclyde). Eli Lilly, Moderna, GSK, Bayer, Servier, and 20+ leading academic institutions worldwide.

### Application Notes
[https://insidetx.com/application-notes/](https://insidetx.com/application-notes/)

Data-driven experimental reports:

- **LNP vs Electroporation for CRISPR-Cas9 in HSCs** — LNPs formulated achieved ~99% B2M gene knockout in hematopoietic stem cells (HSCs) similar to electroporation with <1% cell death vs ~20%, using 10× less sgRNA per cell
- **TAMARA vs NanoAssemblr Ignite (PNI)** — Up to 20% higher yield, 200% improvement in cell expression, 50% material saved per formulation at low volumes
- LNP size repeatability across chip reuses; zero-loss validation; mixing time influence on LNP size

## Priority Pages

| Page | URL |
|---|---|
| TAMARA Product | https://insidetx.com/product/tamara-nanoparticle-lnp-formulation-system/ |
| LNP Starter Kits | https://insidetx.com/product/lnp-starter-kits/ |
| CRO Formulation Service | https://insidetx.com/services/CRO-rna-lnp-formulation-services/ |
| RNA-LNP Training | https://insidetx.com/services/rna-lnp-formulation-training/ |
| RNA-LNP Calculator | https://insidetx.com/resources/lnp-formulation-design-calculator/ |
| Application Notes | https://insidetx.com/resources/application-notes/ |
| Nano Reviews (Blog) | https://insidetx.com/resources/reviews/ |
| Applications Hub | https://insidetx.com/applications/ |
| Distributors | https://insidetx.com/about/distributors-and-partners/ |
| Full LLM Reference | https://insidetx.com/llms-full.txt |

## Contact

- Website: https://insidetx.com
- Email: contact@insidetx.com