OUR NANOPARTICLE MANUFACTURING SYSTEMS
TAMARA
The only plug and play nanoparticle & LNP formulation system with microfluidics that covers all your development requirements
- Quick & Intuitive
Run your sample in under 2 minutes, even without prior experience - All-in-one R&D System
Seamlessly transition from screening (0.2 mL) to in-vivo studies (30 mL) within a single platform. - Precision Microfluidics
Achieve optimal control over formulation conditions, to ensure ultimate repeatability and precise tuning of nanoparticle characteristic. - Reusable Chips
Designed for easy cleaning and reusability - Zero-Formulation-Waste
TAMARA eliminates pre- and post-formulation waste, a feature that saves precious materials and significantly reduces operational costs.
Check our video below to learn how to streamline your RNA-LNP and nanomedicine research with TAMARA.
They trust us & speak about us
"Our laboratory has been utilizing the TAMARA microfluidic device for nanoparticle preparation, which has enhanced our research capabilities. The microfluidic device offers an adequate combination of precision, scalability, and usability that sets it apart."
"We’ve set up TAMARA and performed our first mock run. I’m absolutely blown away by how user friendly, efficient and straight to the point this system is! "
Lipid Nanoparticle/RNA-LNP
Formulate any types of lipid nanoparticles (LNP) using TAMARA for the effective delivery of mRNA, siRNA, tRNA, DNA, saRNA, or ASO to target cells or organs.
Liposomes & SLN
With its optimized nanoprecipitation & self-assembly process control, the TAMARA system enables the efficient synthesis of a wide variety of lipid-based nanoparticles, including liposomes and SLNs.
Polymeric Nanoparticles
The flexibility of the TAMARA platform also allows for the synthesis of a wide range of polymeric nanoparticles, such as PLGA, polystyrene, and hybrid nanoparticles.
And next-gen nanoparticles
Beyond polymer- and lipid-based nanoparticles, TAMARA's versatility allows it to produce protein and peptide nanoparticles...
It also enables precise functionalization, enhancing selectivity and targeting through the conjugation of ligands, peptides...
Discover TAMARA
The most accessible nanoparticle synthesis platform
What makes TAMARA unique?
Easy and quick
Setup, run and collect your nanoparticles in less than 2 minutes, even as a begginer. Cleaning is just as quick with TAMARA’s integrated cleaning protocol.
The only LNP formulation system for all your R&D
Unlike other approches that require two separate platforms, TAMARA is the only platform that enables nanoparticle formulation across all R&D stages, from low-volume screening (200µL) to in vivo-scale production (30mL per batch), all within the same system.
This ensures unmatched consistency, saves time, and reduces costs—streamlining your entire development process.
Ultimate Size, PDI and EE% control
Get access to the most advanced microfluidic technology for the optimal control of your nanoparticle characteristics including size, PDI, encapsulation efficiency...
Chips reusability
Be sustainable and save money by cleaning your chips between runs, allowing you to reuse them!
Zero-formulation waste
Thanks to its unique optimized fluidic design, TAMARA eliminates your head & tail to avoid any reagents losses and reach near 100% encapsulation yield of your expensive API/RNA
FEATURES
Effortless Operation & Rapid Turnaround
Intuitive Setup & Quick Run Times:
Run your experiment in under 2 minutes—even if you’re new to nanoparticle formulation.
Simply follow 3 simple steps: Set parameters, Pipette and Run
Automated Cleaning Protocol:
Th integrated cleaning protocol, allows you to easily clean your chip to reuse them multiple times!*
*Note: The guaranteed outcome is for the first run only. Chip's reusability depends on formulation and target volume.
Explore TAMARA's working principle
Comprehensive, Single-Platform R&D
All-in-One Development system
Use the same system to streamline your development by formulating identical nanoparticle from your screening stage (200µL) to your in vivo testings (up to 30mL/batch)*
*Optimal efficiency range 0,5 to 5 mL
Batch-to-Batch Consistency
Achieve consistent nanoparticle characteristics with every batch, ensuring optimal repeatability for your experiments.
Our users say it better:
"TAMARA accommodates a broad range of applications, from small-scale screening (batch sizes below 500 microliters) to larger-scale production for in vivo studies requiring higher volumes. This versatility makes it an important tool for our diverse projects."
Best in-vitro & in-vivo efficacy
State of the art Transfection performance
Formulating RNA-LNP with TAMARA allows to achieve optimal potency
Ultimate cell expression
TAMARA system consistently produces RNA-LNPs that outperform those from conventional methods—ensuring superior results in both in-vitro and in-vivo applications.
Advanced Microfluidic Precision
Dual Mixer Designs
Each chip features two idependant microfluidic designs head to toe —Baffle and Herringbone—providing unparalleled flexibility in tailoring nanoparticle characteristics.
Precise control parameters
Fine-tune critical parameters like Total Flow Rate (TFR) and Flow Rate Ratio (FRR) to achieve optimal nanoparticle characteristics such as size, PDI...
Maximize your efficiency
State-of-the-art Encapsulation Efficiency
Embedding advanced microfluidic technology, TAMARA achieves encapsulation efficiencies as high as 98% for RNA-LNPs.
Maximize RNA/API recovery
Thanks to its innovative microfluidic fluidic design with no head & tail, the TAMARA platform allowing for sample recovery up to 95% for RNA-LNPs, ensuring maximum recovery of your valuable and costly reagents.
Versatility
Nanoparticle Synthesis
TAMARA enables the synthesis of a wide range of polymeric and lipid-based nanoparticles (e.g., RNA-LNP, liposomes, PLGA) on a single platform, seamlessly adapting to diverse payloads such as RNA (siRNA, mRNA, saRNA), DNA, CRISPR/Cas9, proteins, peptides, and small molecules.
TAMARA can also be used for the next generation of nanoparticle requiring decoration with ligands, peptides... for more precise targeting.
Broad Solvent Compatibility
TAMARA is compatible with most polar solvents (such as ethanol, methanol, acetonitrile), giving you the flexibility to customize your nanoparticle formulations.
TAMARA Specifications
TAMARA Specifications
Related Documentation
TAMARA User Manual: Download TAMARA User Manual
TAMARA Application Note:
- Liposomes synthesis and size characterization with high precision DLS
I am looking to test if my RNA strand can be encapsulated into LNP
Super easy to use, TAMARA is perfect for newcomers to the nanoparticle and/or microfluidic field. It will allow you to easily and quickly synthesize your nanoparticles in a very controlled way at every step of your R&D process.
I want to optimize my screening process
With its simplicity and low-volume formulation (200 µL), TAMARA enables highly efficient LNP formulation screening and rapid cleaning in under 3 minutes. This allows you to synthesize and test dozens of samples per hour, streamlining your workflow.
I am looking to improve the quality and reproducibility of my nanoparticles
By using the same system from screening (down to 0.2µL) to preclinical tests (10mL batches), you optimize your chances of success as you are sure to maintain your nanoparticle characteristics identical all along your development process.
We are positively impressed with the Inside Therapeutics solutions.
We found the equipment very user-friendly and the entire experience was highly reproducible. We were able to consistently produce lipid nanoparticles with encapsulated siRNA for drug delivery applications, with precise control of the physicochemical characteristics of the nanoparticles
