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OUR NANOPARTICLE SYNTHESIS PLATFORMS

Lipid nanoparticle synthesis pack

The most flexible nanoparticle synthesis platform:

  • Manufacture most nanoparticle types using the same platform: liposomes, LNP-xRNA, SLN, PLGA...
  • Benefit from the best of microfluidics expertise for the most optimal control of LNP characteristics: Size, PDI, Encapsulation efficiency
  • Use the same system from mL to 10s of mL
  • Automate your formulation using our integrated environment
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Reusable chips

Environmental friendly solution as chips can be reused multiple times (10 or more if properly cleaning)

Flexible platform

A fully customizable platform to accomodate any of your requirements in terms of automation and volumes

Microfluidics

Achieve the best nanoparticle characteristics control thank to our advanced microfluidic platform: 
Excellent repeatability (5%), size control, PDI (<0.2) and encapsulation efficiency (>95% for RNA-LNP)

FEATURES

Ultimate control of your nanoparticle size

Get the nanoparticle size you want

Easily fine tune your nanoparticle size to obtain the best experimental results using our state of the art microfluidics mixers.

Achieve the best homogeneity

Optimize your nanoparticule population size, to obtain the lowest polydispersity index (PDI)

TFR impact on nanoparticle size for different cationic lipid using herringbone microfluidics mixer
TFR impact on nanoparticle size for different cationic lipid using herringbone microfluidics mixer
Encapsulation efficiency of ARN in LNP with a microfluidic herringbone mixer
Encapsulation efficiency of ARN in LNP with a microfluidic herringbone mixer

Achieve optimal results

Benefit from the best of microfluidics to achieve an optimal control of your nanoparticle parameters:

  • Size homogeneity (PDI) <0.2
  • Encapsulation Efficiency (EE%) > 90%
  • Reproducibility > 3%

Use the same platform all along your development process

Using state of the art instrumentation, our platform will allow you to work at nearly any scale required by your project

Platform automation

Thanks to its design flexibility, the lipid nanoparticle pack can be tuned to

  • Remove head and tail for optimal sample quality control
  • Automate cleaning steps

Perfect for larger scale production

The pressure driven technology allows the work from mL to L scales.

Nanoparticle size repeatability at different volumes
LNP size repeatability at different volumes
LNP observed with CRYO TEM
LNP observed with CRYO TEM

Synthesize most nanoparticles types

The nanoparticle synthesis pack is best suited for any nanoparticle that can be manufactured by nanoprecipitation (LNP, Liposomes, SLN...)

Fine tune your composition

Easily solvent, composition so you can find the best fit for your application!

Check out our comprehensive userguide to:

  • Better understand microfluidic based nanoparticle synthesis 
  • Check out the pack composition
  • Have a look at the installation protocol
Lipid nanoparticle generation system with microfluidics
Download LNP Pack Userguide to learn more

We are positively impressed with the Inside Therapeutics solutions. They provided us with detailed instructions to set up the equipment, which made the system quick and easy to start. We found the equipment very user-friendly and the entire experience was highly reproducible. We were able to consistently produce lipid nanoparticles with encapsulated siRNA for drug delivery applications, with precise control of the physicochemical characteristics of the nanoparticles

Ronny Vargas Monges
Universitat de Barcelona

Ready to Innovate? Reach Out to Us to Your Get your Custom Nanoparticle Synthesis platform!




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