TAMARA vs NanoAssemblr Benchtop

A Modern Alternative to NanoAssemblr Benchtop for LNP Formulation

The NanoAssemblr Benchtop has long been a reference system for microfluidic lipid nanoparticle (LNP) formulation. It played a key role in early mRNA-LNP, siRNA, and nucleic acid delivery research, enabling reproducible, small-scale LNP production through controlled microfluidic mixing.

However, the NanoAssemblr Benchtop has now been discontinued, and the Nanoassemblr cartridges not availables anymore. It has been replaced by the NanoAssemblr Ignite, a newer platform built on the same core microfluidic principles but relying exclusively on single-use, non-reusable chips.

In contrast, TAMARA was specifically designed to overcome the limitations of the NanoAssemblr Benchtop—notably higher working volumes and formulation losses—while preserving the flexibility of reusable microfluidic chips. Thanks to its integrated cleaning protocol, TAMARA enables efficient low-volume LNP formulation without the constraints associated with disposable-only systems.

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NanoAssemblr Benchtop vs TAMARA for LNP formulation

TAMARA & NanoAssemblr Benchtop comparison table

Nanoparticle/LNP formulation system	TAMARA Inside Therapeutics	NanoAssemblr Benchtop Cytiva
General
Technology	Microfluidic mixing system	Microfluidic mixing system
RNA-LNP formulation	✔	✔
PDI	✔	✔
Performance
Repeatability & Control	Control over TFR, FRR & Total volume	Control over TFR, FRR & Total volume
Volume Range	0.2 – 30 mL	~1 – 20 mL
Waste Volume (head & tail)	0 µL	≥ 300 µL
Applications
Screening	✔	≥ 1 mL
In Vitro	✔	✔ (≥ 1 mL)
In Vivo	✔	✔
User Experience
Ease of Use	✔	✔
Learning Time	< 30 mins	< 30 mins
Average Time per Formulation	< 2 mins	< 2 mins
Integrated Cleaning / Chip Reusability	✔	No
Risk of Cross Contamination	Low (cleanable or single use)	Low (cleanable or single use)
Chip Cost (per chip)	~$49 / €42 (pack of 10)	Discontinued

Learn more about TAMARA

Why consider TAMARA as an alternative to NanoAssemblr BenchTop?

Minimal material losses

TAMARA maximizes your material use to achieve a near 100% mRNA recover

Ultimate flexibility

TAMARA supports you across all R&D stages from small-scale screening to larger in-vivo study volumes

Availability

TAMARA chips are available and reusable, while the Nanoassemblr Benchtop Cartridges are not availables anymore

Looking for a comparison?

See how the 2 systems compare in terms of mRNA recovery

Still deciding between RNA-LNP formulation systems?

Check this comment from one of the TAMARA Users

Hear from Our Users

Full Professor at UMC Utrecht, President of Nanomedicine European Technology Platform (ETPN), Editor of IJP and JCR.

Prof. Raymond Schiffelers

It’s only through daily use that the true value of a machine becomes apparent. When PhD students consistently gravitate toward one device while overlooking others, it speaks volumes. Tamara is in high demand—an endorsement in itself

Professor at the University of Santiago de Compostela, Editor-in-Chief of the Drug Delivery and Translational Research,

Prof. Maria Jose Alonso

Our laboratory has been utilizing the TAMARA microfluidic device for nanoparticle preparation, which has enhanced our research capabilities. The microfluidic device offers an adequate combination of precision, scalability, and usability that sets it apart.

Research and development scientist in stealth biotech company

Dzenan Kovacic

We’ve set up TAMARA and performed our first mock run. I’m absolutely blown away by how user friendly, efficient and straight to the point this system is!

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Final Thoughts: NanoAssemblr Benchtop vs. TAMARA

The NanoAssemblr Benchtop used to be a popular system in the LNP field — but if your research requires higher flexibility, reduced waste, and lowered cost per run, TAMARA is a compelling alternative. By combining precision microfluidics with practical usability, TAMARA enables researchers to move faster from screening to in-vivo testing without being limited by scale.

Download our comparative Application note Nanoassemblr vs TAMARA for low volume mRNA-LNP Formulation

LNP Formulation Inside Therapeutics Contact

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