Nanoparticles Reviews

An introduction to novel LNP targeting strategies for optimizing RNA-LNP biodistribution and improving cell specificity

LNP targeting has become the key limiting factor for expanding RNA therapeutics beyond liver-centric applications.…

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RNA Transfection Methods: Comparative Overview

RNA transfection methods are essential tools for studying gene function and developing RNA-based therapeutics,…

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Self‑Amplifying RNA versus Conventional mRNA – A Forward‑Looking Comparison

Self amplifying RNA (saRNA) is a next-generation RNA vaccine platform that replicates within cells, achieving strong…

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What are lipid-based nanoparticles?

Lipid-based nanoparticles (LBNPs) are advanced delivery systems designed to transport therapeutic molecules with high…

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Understanding the key role of Ionizable Lipids in novel RNA-lipid nanoparticle therapies

Ionizable lipids are key enablers of recent RNA–LNP therapies and vaccines, enabling efficient encapsulation and…

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Solid lipid nanoparticles: an introduction

This introduction to solid lipid nanoparticles (SLNs) highlights their role as biocompatible, versatile delivery…

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RNA-LNP vaccines: The Role of Lipid Nanoparticle Compositions

This guide explains how lipid nanoparticle (LNP) composition critically shapes mRNA Lipid Nanoparticle vaccine and RNA…

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RNA-LNP Morphology: A Comprehensive Review

RNA-LNP morphology is a pivotal quality attribute shaped by lipid composition, formulation conditions, and buffer…

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Microfluidic synthesis of lipid nanoparticles

The microfluidic synthesis of lipid nanoparticles has emerged as a transformative approach—propelled by the success…

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Mastering Thin Film Hydration Method for Liposome and Lipid Nanoparticle Formulation

This review gives a detailed description of the Thin Film Hydration Method, first available technique for Liposomes and…

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LNP and liposomes characterization guidelines

This guide outlines essential methods for lipid nanoparticles (LNPs) and liposomes characterization, detailing how…

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Liposomes vs Lipid Nanoparticles as vehicles for delivery applications

Liposomes vs lipid nanoparticles is a key comparison in drug delivery research. This article explains their structural…

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Lipid-based nanoparticles drug delivery for cancer therapies

Modern nanomedicine leverages lipid-based nanoparticles for cancer therapies to achieve precise drug delivery. The…

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Lipid Nanoparticle for mRNA delivery

As a leading platform, Lipid Nanoparticles for mRNA delivery are protecting fragile RNA, ensuring cellular uptake, and…

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Introduction to PLGA Nanoparticles as a Drug Delivery System

Poly(lactic-co-glycolic acid) i.e. PLGA nanoparticles (PLGA NPs) are biodegradable, FDA/EMA-approved drug delivery…

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How to optimize lipid nanoparticle formulation?

Optimizing lipid nanoparticle (LNP) formulation is pivotal for advancing RNA therapeutics. In this review, we outline…

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Fundamentals of microfluidic mixing for LNP synthesis

Microfluidic mixing offers unparalleled control over lipid nanoparticle (LNP) formation by finely tuning mixing speed,…

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Fundamentals of lipid nanoparticles formation mechanism by nanoprecipitation

LNP formation—also known as lipid nanoparticle formation—relies on nanoprecipitation or self-assembly mechanisms…

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Exploring LNP Size and its Significance in Drug Delivery

. The LNP size is a, if not the most important, critical factor influencing RNA delivery performance, from…

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Dialysis: a key and underestimated factor for the synthesis of lipid nanoparticle by microfluidics

This research summary reveals that dialysis for lipid nanoparticles, a purification step often underestimated,…

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