Nanoparticles Reviews

In Vivo CAR-T Engineering: The Emerging Role of mRNA–LNP Technologies

In-vivo CAR-T therapy is emerging as a next-generation approach to overcome the cost, complexity, and logistical…

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LNP Hand Mixing: Why LNP mixing methods matter, and Comparison with Microfluidic Mixing

LNP hand mixing is widely used for RNA-LNP formulation due to its simplicity and minimal equipment requirements.…

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An introduction to novel LNP targeting strategies for optimizing RNA-LNP biodistribution and improving cell specificity

LNP targeting has become the key limiting factor for expanding RNA therapeutics beyond liver-centric applications.…

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From discovery to clinic: bridging scales in RNA-LNP manufacturing

RNA–lipid nanoparticles (RNA–LNPs) have emerged as the leading delivery platform for RNA therapeutics, yet…

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RNA Transfection Methods: Comparative Overview

RNA transfection methods are essential tools for studying gene function and developing RNA-based therapeutics,…

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Self‑Amplifying RNA versus Conventional mRNA – A Forward‑Looking Comparison

Self amplifying RNA (saRNA) is a next-generation RNA vaccine platform that replicates within cells, achieving strong…

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What are lipid-based nanoparticles?

Lipid-based nanoparticles (LBNPs) are advanced delivery systems designed to transport therapeutic molecules with high…

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Using Lipid nanoparticle (LNP) for CRISPR-CaS9 delivery

Lipid nanoparticles (LNPs) are revolutionizing CRISPR-Cas9 delivery by protecting RNA payloads and enhancing cellular…

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Understanding the key role of Ionizable Lipids in novel RNA-lipid nanoparticle therapies

Ionizable lipids are key enablers of recent RNA–LNP therapies and vaccines, enabling efficient encapsulation and…

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The Evolution of Nanomedicine: from ideas to clinical applications

Nanomedicine addresses limitations of conventional medicine through nanoscale engineering, enabling targeted drug…

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Solid lipid nanoparticles: an introduction

This introduction to solid lipid nanoparticles (SLNs) highlights their role as biocompatible, versatile delivery…

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RNA-LNP vaccines: The Role of Lipid Nanoparticle Compositions

This guide explains how lipid nanoparticle (LNP) composition critically shapes mRNA Lipid Nanoparticle vaccine and RNA…

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RNA-LNP Morphology: A Comprehensive Review

RNA-LNP morphology is a pivotal quality attribute shaped by lipid composition, formulation conditions, and buffer…

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Revolutionizing Gene Therapy: Screening Lipid Nanoparticles for optimal delivery of mRNA and CRISPR-Cas9

A high-throughput screening of nanoparticles for gene therapy evaluated 720 lipid nanoparticle (LNP) formulations for…

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mRNA-LNP vaccines

This review explains mRNA vaccines, highlighting their mechanism, advantages, and limitations. It covers LNP-based…

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mRNA Vaccines for Pancreatic cancer advancement

Researchers at Memorial Sloan Kettering Cancer Center are advancing mRNA vaccines for pancreatic cancer by designing…

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mRNA LNP Revolution: Unlocking New Frontiers in Pharmaceuticals, Vaccines, and Therapeutics

mRNA–LNP (Lipid nanoparticles) are redefining modern therapeutics by enabling precise, safe, and efficient delivery…

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Microfluidic synthesis of lipid nanoparticles

The microfluidic synthesis of lipid nanoparticles has emerged as a transformative approach—propelled by the success…

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Mastering Thin Film Hydration Method for Liposome and Lipid Nanoparticle Formulation

This review gives a detailed description of the Thin Film Hydration Method, first available technique for Liposomes and…

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LNP synthesis: Overview of the manufacturing methods

This review on LNP manufacturing provides a comprehensive overview of LNP synthesis methods, spanning from traditional…

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