TAMARA vs Unchained Labs for LNP Formulation
Looking for the best microfluidic-based nanoparticle or RNA-LNP formulation system?
TAMARA by Inside Therapeutics and the Unchained labs Sunshine (former Particle Works) are both excellent options. Let’s compare their key features to help you decide.
TAMARA & Sunshine comparison table
Why Choose TAMARA Over Unchained Labs Sunshine?
Zero Sample Loss
TAMARA ensures 0 μL loss per formulation, saving valuable reagents—perfect when working with expensive RNA or limited materials.
The Unnchained labs Sunshine, by comparison, requires at loss 300 μL loss per run to remove head and tail.
Versatile Application:
Low to Large Volumes
TAMARA supports volumes as low as 0.2 mL and up to 30 mL, making it perfect for early-stage studies, screening, in vitro, and in vivo applications. Sunshine, with a minimum volume of 1 mL, lacks screening functionality and provides only partial capabilities for in vitro studies.
Ease of Use without risks of cross contamination
TAMARA’s user friendly design allows for very simple formulation simply by setting formulation parameters, pipetting your RNA & LNP in the system and pressing on play/
In contrast, Unchained labs Sunshine’s overly complex design can be overwhelming, and its carrier-fluid-based system increases the risk of cross-contamination.
Why Choose Unchained Labs Sunshine Over TAMARA for LNP formulation?
Higher Volume Capacity
Sunshine accommodates formulations up to L, making it suitable for larger-scale projects. TAMARA’s capacity maxes out at 30 mL.
However, it’s important to note that microfluidic systems become highly prone to clogging at volumes exceeding 100 mL, making them less reliable for large-scale production.
Automation
Sunshine enables automated testing of different formulation conditions (TFR & FRR), allowing up to five samples to be processed simultaneously. However, this comes at the cost of significantly increased complexity.
In contrast, TAMARA streamlines the process, delivering formulations in under 2 minutes per sample with a far simpler and more user-friendly approach.
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TAMARA vs Sunchine: Key takeaways:
- Choose TAMARA if you need a system that covers all the R&D development steps, with low sample loss, screening capabilities and simplicity of use. It’s perfect for researchers working with small volumes or requiring versatility across applications at R&D scale.
- Choose Sunshine if you prioritize higher volume capacity and seek basic automated formulation screening at the cost of higher complexity.
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