In partnership with Quantoom Biosciences
RNA production:
ready-to-use, scalable
Meet Ntensify® micro and mini — construct-agnostic
(sa)mRNA synthesis systems that take you from high
throughput screening to scalable production, with
one optimized and redisgned process
One process from screening to scale-out
Up to 96 constructs in parallel
Construct-agnostic — no re-development
POWERED BY QUANTOOM’S PROVEN NTENSIFY PLATFORM
+30
equipment installed
3
already under GMP
+10
pre-clinical platform validation
FDA
drug master file under filing
What can Ntensify do?
Whether you’re screening lipid formulations or scaling a lead construct,
Ntensify delivers your RNA — without re-developing your process.
Constructs
mRNA 1–4 kb and saRNA 8–12 kb
Up to 96 different constructs in parallel
Construct-agnostic process —
validated on 100+ constructs
Output & scale
From 175 µg to 100 mg of mRNA
96-well screening at 100 µL · production
at 20 mL
20mL available either as RUO or GMP
Applications
High-throughput mRNA & library screening
Suitable for in vivo testing: ADME/Tox, dose escalation, tolerance
Demonstrated track record in Infectious disease, oncology & animal health
What makes Ntensify
the best system for your needs?
One process from
screening to scale-out
Reagents & disposables matched to your equipment
GMP-ready automation, de-risked from day one
Two minutes only to understand Ntensify
See how the Ntensify Process streamlines mRNA synthesis — from reagent mix to purified output — with a workflow your team can run on day one.
Load → Transcribe → Purify
It’s that simple!
THE SYSTEMS
Two systems. One Ntensify Process.
Start at the bench with micro, scale to automation with mini — the same reagents, disposables and protocol throughout.
Manual ● benchtop
Ntensify micro
For diverse screening needs and scalable production – fits under a laminar flow hood.
| Constructs | Up to 96 (5 μg DNA each) |
| Output | 175 μg – 100 mg mRNA |
| Format | 96-well (100 μg) – 20 mL |
| Automation | Manual – touchscreen control |
| Footprint | 34 x 32 x 18 cm – 11 kg |
Automated ● enclosed
Ntensify mini
Fully automated parallel production – GMP-ready process in an enclosed system for research use.
| Constructs | Up to 96 in parallel |
| Output | pending spec sheet |
| Format | pending spec sheet |
| Automation | Fully automated – < 1 day |
| Footprint | pending spec sheet |
The Ntensify Process
An integrated, intensified workflow
Ntensify is more than an instrument. It’s a complete, construct agnostic production system — the same protocol, reagents and disposables across every scale, mirroring GMP-ready automation from your first screen to scalable production.
Reagent mixes equivalent to our automated systems — reducing
experimental variability between micro and mini.
Demonstrated track record — Succesfully tested in multiple pre
clinical studies on a broad range of indications.
Plug-and-play integration — the Ntensify Process protocol ships
ready to run.
PROCESS
One validated protocol, construct to construct
REAGENTS
Optimized mixes for consistent 20 mL IVT.
DISPOSABLES
Matched consumables across every scale.
EQUIPMENT
micro & mini – bench to automated production.
Where are you in your mRNA journey?
Find your profile and the right system to start with.
You already run mRNA process development
What Ntensify changes for you
Screen up to 96 constructs in parallel –
same protocol at every scale
Reagent mixes equivalent to automated systems – less variability
All-in-one, including modified uridines and TriLink’s CleanCAP®
You’re adding mRNA
to your pipeline
What you get with Ntensify
A construct-agnostic process –
no re-development per new RNA
One platform from cell assays to in-vivo studies
Onboarding program: protocols, training and expert support
With you at every step
From your first question to daily use — Inside Therapeutics and Quantoom, together.
Discovery
See how Ntensify fits your science — no commitment
Start with a small scale evaluation using Ntensify mano kit
Talk to our mRNA specialists to see how to further optimize your sequence
Installation
We get you up and running
Setup, onboarding and IQ/OQ
Hands-on mRNA training program
Long term support
A real partnership doesn’t stop at the delivery
Dedicated technical support
Reagent supply & maintenance plans
Frequently asked questions about Ntensify
What is the difference between Ntensify micro and mini?
micro is a manual benchtop system for screening and scalable production that fits under a laminar flow hood; mini is a fully automated, enclosed system for parallel production. Both run the same Ntensify Process.
How many constructs can I run at once?
Up to 96 different constructs in parallel — at 100 µL per well for screening, scaling to 20 mL per reaction for production.
Do I need to re-develop my process for each new construct?
No. The Ntensify Process is construct-agnostic and validated across 100+ constructs (mRNA 1–4 kb, saRNA 8–12 kb), so you don’t re-tune per new RNA.
How much mRNA can the system produce?
Ntensify micro produces from 175 µg up to 100 mg of mRNA, with no scale-up required beyond 20 mL.
Is the process GMP-ready?
The Ntensify Process mirrors GMP-ready automation, and a drug master file is in registration with the FDA. Three sites already operate under GMP.