Application notes

An in vitro comparison of mRNA and CRISPR-Cas9 transfection efficiency and genome-editing performance using lipid nanoparticles and electroporation in primary hematopoietic stem cells. Introduction CRISPR–Cas9 technology has revolutionized genome engineering, enabling precise and programmable editing for therapeutic applications. Its use is expanding rapidly across fields such as immuno-oncology, hematology, and regenerative medicine. Discovered in the … Continued

This study provides a comprehensive evaluation of the TAMARA nanoparticle formulation system, focusing on its performance at low volumes to optimize RNA-LNP formulations while minimizing the use of costly mRNA. Additionally, a comparative analysis is conducted with the widely-used toroidal mixer, allowing for a clear assessment of both systems’ capabilities. Both systems produced high-quality RNA-LNPs … Continued

Evaluating low volumes formulation performance and benchmarking against mainstream toroidal microfluidic mixers